However, significant limitations exist in the current evidence: Most human data comes from small studies, with limited randomised controlled trials specifically designed to assess alcohol consumption The mechanisms by which GLP-1 medications might reduce alcohol intake are not fully understood Individual responses vary considerably, and not all patients experience changes in drinking behaviour Long-term effects and safety of using these medications specifically for alcohol reduction remain unknown The MHRA has not approved GLP-1 receptor agonists for alcohol use disorder, and these medications should not be considered a treatment for problematic drinking
141:4021-4031 [PubMed: 11089532] 80
Prescription weight loss medications have come a long way
They target different receptors (two versus three), have different pharmacokinetics, and produce different metabolic effects per milligram
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[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Moon J., Koh G
